From my life experience, if there is one thing that I have learned, is to be happy no matter where I am in life. Not just because I want to keep myself deluded and oblivious to the “pain” or whatever “unease” I may be feeling, but because I want to genuinely be happy. I am also tired of feeling uneasy and unhappy in life.
This goes back to everything leading to God. Everything can and will end except God. So every sorrow and every pain will eventually end too.